Trials
INTREPID
In critically ill adult patients with acute vascular brain injury (ischemic stroke, ICH, or SAH), does active fever prevention targeting 37.0°C using an automated surface device, compared with standard reactive fever treatment, improve functional outcome at 3 months?
INTERACT2
In patients with acute intracerebral hemorrhage does intensive blood pressure control (target systolic BP <140 mmHg) improving functional outcome at 90 days as compared with standard care (target systolic BP <180 mmHg)?
INCH
In adult patients with VKA-associated intracerebral hemorrhage (INR ≥2.0, symptoms <12h), does prothrombin complex concentrate (PCC) compared with fresh frozen plasma (FFP), both with vitamin K, lead to more rapid and effective INR normalization and affect hematoma expansion and clinical outcomes?
i-DEF
In adult patients (18-80 years) with primary spontaneous supratentorial intracerebral hemorrhage, does deferoxamine mesylate (32 mg/kg/day for 3 days) initiated within 24 hours, compared with placebo, show sufficient promise of improving functional outcome (mRS 0-2) at 90 days to warrant a phase 3 trial (i.e., not futile)?
FAST
In adult patients with acute intracerebral hemorrhage treated within 4 hours of onset, does recombinant activated factor VII (rFVIIa) at doses of 20 μg/kg or 80 μg/kg, compared with placebo, reduce death or severe disability at 90 days?
ENRICH
In adult patients (18-80 years) with spontaneous supratentorial intracerebral hemorrhage (lobar or basal ganglia, volume 30-80 mL, GCS 5-14), does early minimally invasive parafascicular surgery (MIPS) plus medical management, compared with medical management alone, improve functional outcome (utility-weighted mRS) at 180 days?
CLEAR III
In adult patients (18-75 years) with spontaneous supratentorial ICH (<30 mL) and obstructive IVH requiring an EVD, does intraventricular administration of alteplase via the EVD, compared with EVD management with or without saline irrigation, improve functional outcome at 180 days?
ATACH-2
In patients with acute intracerebral hemorrhage and SBP ≥180 mmHg, does intensive blood pressure control (target SBP 110-139 mmHg) reduce death or disability at 3 months compared with standard care (target SBP 140-179 mmHg)?