Warfarin Reversal

Published in The Lancet Neurology
Intracerebral HemorrhageHemostasis Reversal Agents Anticoagulant Reversal Prothrombin Complex Concentrate (PCC) Fresh Frozen Plasma (FFP) Warfarin Reversal

In adult patients with VKA-associated intracerebral hemorrhage (INR ≥2.0, symptoms <12h), does prothrombin complex concentrate (PCC) compared with fresh frozen plasma (FFP), both with vitamin K, lead to more rapid and effective INR normalization and affect hematoma expansion and clinical outcomes?