Thrombolysis (Alteplase)
MISTIE III
In adult patients (18-80 years) with spontaneous supratentorial intracerebral hemorrhage (volume ≥30 mL, GCS 4-14), does minimally invasive catheter evacuation followed by alteplase instillation, compared with standard medical care alone, improve functional outcome (mRS 0-3) at 365 days?
CLEAR III
In adult patients (18-75 years) with spontaneous supratentorial ICH (<30 mL) and obstructive IVH requiring an EVD, does intraventricular administration of alteplase via the EVD, compared with EVD management with or without saline irrigation, improve functional outcome at 180 days?
More topics:
- Acute Blood Pressure Control
- Andexanet Alfa
- Anti-fibrinolytic Therapy
- Anticoagulant Reversal
- Antiplatelet Therapy Complications
- Craniotomy
- Deferoxamine
- External Ventricular Drain (EVD)
- Factor VIIa
- Factor Xa Inhibitor Reversal
- Fever Prevention
- Fresh Frozen Plasma (FFP)
- Glucose Control
- Hematoma Evacuation
- Hematoma Expansion
- Hemostasis
- Imaging Biomarkers
- Insulin Therapy
- Intraventricular Hemorrhage
- Iron Chelation
- Ischemic Stroke Management
- Minimally Invasive Surgery
- Neurocritical Care
- Neuroprotection
- Neurosurgical Intervention
- Prothrombin Complex Concentrate (PCC)
- Reversal Agents
- Secondary Brain Injury
- Supportive Care
- Temperature Management
- Thrombolysis (Alteplase)
- Tranexamic Acid
- Warfarin Reversal