Supportive Care

SHINE

Acute Ischemic Stroke

In adult patients with acute ischemic stroke and hyperglycemia, does intensive glucose control (target 80-130 mg/dL with IV insulin) compared with standard glucose control (target 80-179 mg/dL with subcutaneous insulin) improve functional outcome at 90 days?

INTREPID

Acute Ischemic Stroke Intracerebral Hemorrhage Subarachnoid Hemorrhage

In critically ill adult patients with acute vascular brain injury (ischemic stroke, ICH, or SAH), does active fever prevention targeting 37.0°C using an automated surface device, compared with standard reactive fever treatment, improve functional outcome at 3 months?