Reversal Agents

Published in The Lancet
Intracerebral HemorrhageHemostasis Reversal Agents Antiplatelet Therapy Complications

In adult patients (GCS ≥8) with spontaneous supratentorial intracerebral hemorrhage who were on antiplatelet therapy and presented within 6 hours, does platelet transfusion plus standard care, compared with standard care alone, reduce death or dependence at 3 months?

Published in The Lancet Neurology
Intracerebral HemorrhageHemostasis Reversal Agents Anticoagulant Reversal Prothrombin Complex Concentrate (PCC) Fresh Frozen Plasma (FFP) Warfarin Reversal

In adult patients with VKA-associated intracerebral hemorrhage (INR ≥2.0, symptoms <12h), does prothrombin complex concentrate (PCC) compared with fresh frozen plasma (FFP), both with vitamin K, lead to more rapid and effective INR normalization and affect hematoma expansion and clinical outcomes?

Published in New England Journal of Medicine
Intracerebral HemorrhageHemostasis Reversal Agents Factor VIIa

In adult patients with acute intracerebral hemorrhage treated within 4 hours of onset, does recombinant activated factor VII (rFVIIa) at doses of 20 μg/kg or 80 μg/kg, compared with placebo, reduce death or severe disability at 90 days?