Hemostasis
TICH-2
In adult patients with acute spontaneous intracerebral hemorrhage treated within 8 hours of onset, does tranexamic acid, compared with placebo, improve functional outcome (mRS score) at 90 days?
STOP-AUST
In adult patients with acute spontaneous intracerebral hemorrhage and a CT angiography spot sign, treated within 4.5 hours of onset, does tranexamic acid, compared with placebo, reduce hematoma expansion at 24 hours?
PATCH
In adult patients (GCS ≥8) with spontaneous supratentorial intracerebral hemorrhage who were on antiplatelet therapy and presented within 6 hours, does platelet transfusion plus standard care, compared with standard care alone, reduce death or dependence at 3 months?
INCH
In adult patients with VKA-associated intracerebral hemorrhage (INR ≥2.0, symptoms <12h), does prothrombin complex concentrate (PCC) compared with fresh frozen plasma (FFP), both with vitamin K, lead to more rapid and effective INR normalization and affect hematoma expansion and clinical outcomes?
FAST
In adult patients with acute intracerebral hemorrhage treated within 4 hours of onset, does recombinant activated factor VII (rFVIIa) at doses of 20 μg/kg or 80 μg/kg, compared with placebo, reduce death or severe disability at 90 days?
ANNEXA-I
In adult patients with acute major bleeding (including ICH) associated with recent use of a factor Xa inhibitor, does andexanet alfa, compared with usual care, result in better hemostatic efficacy and improved clinical outcomes?
More topics:
- Acute Blood Pressure Control
- Andexanet Alfa
- Anti-fibrinolytic Therapy
- Anticoagulant Reversal
- Antiplatelet Therapy Complications
- Craniotomy
- Deferoxamine
- External Ventricular Drain (EVD)
- Factor VIIa
- Factor Xa Inhibitor Reversal
- Fever Prevention
- Fresh Frozen Plasma (FFP)
- Glucose Control
- Hematoma Evacuation
- Hematoma Expansion
- Hemostasis
- Imaging Biomarkers
- Insulin Therapy
- Intraventricular Hemorrhage
- Iron Chelation
- Ischemic Stroke Management
- Minimally Invasive Surgery
- Neurocritical Care
- Neuroprotection
- Neurosurgical Intervention
- Prothrombin Complex Concentrate (PCC)
- Reversal Agents
- Secondary Brain Injury
- Supportive Care
- Temperature Management
- Thrombolysis (Alteplase)
- Tranexamic Acid
- Warfarin Reversal