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In adult patients with acute spontaneous intracerebral hemorrhage treated within 8 hours of onset, does tranexamic acid, compared with placebo, improve functional outcome (mRS score) at 90 days?
In adult patients (≥18 years) with spontaneous supratentorial intracerebral hemorrhage (volume 10-60 mL, GCS 5-12, pre-ICH mRS 0-1), does early surgical hematoma evacuation (within 24 hours) plus medical care, compared with initial conservative medical care alone, improve functional outcome (mRS score) at 180 days?
In adult patients with acute spontaneous intracerebral hemorrhage and a CT angiography spot sign, treated within 4.5 hours of onset, does tranexamic acid, compared with placebo, reduce hematoma expansion at 24 hours?
In adult patients with spontaneous superficial lobar intracerebral hemorrhage (10-100 mL, GCS ≥6T/7), does a policy of early surgical hematoma evacuation by craniotomy plus best medical treatment, compared with best medical treatment alone (with delayed surgery if needed), improve outcome at 6 months?